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Nuphedrine is a non-prescription diet pill designed to help dieters burn more calories every day with the aid of thermogenesis and appetite suppression. The product reportedly helps to enhance weight loss, increase lean muscle mass, suppress appetite and improve athletic performance.

At the time that this review was written, Nupehdrine’s “clinically proven weight loss technology” that made up its proprietary formula included: Advantra-Z (citrus aurantium), Hoodia Gordonii, and Slimaluma (caralluma fimbriata).

That being said, of these three ingredients, it is the Advantra-Z and Hoodia Gordonii that are the most raved about by the manufacturer of the product. According to the official Nuphedrine website, the Advantra-Z within the product is “clinically proven to increase the metabolism to burn more calories per day…even when resting!” It also claims that “Advantra-Z is clinically proven to burn 500 more calories per day.” Unfortunately, the site provides no references to studies to back up these claims.

Since the site offers nothing more than unsubstantiated claims for Nuphedrine, it’s better to take a closer look at the substance citrus aurantium. More frequently called bitter orange, citrus aurantium contains a stimulant known as synephrine, which became all the rage in the OTC weight loss market once ephedra was banned. Synephrine increases heart rate by stimulating the central nervous system. This can boost metabolism and trigger thermogenesis (a process where fat is burned as fuel to heat up the body).

That being said, what some research has found is that synephrine may produce unpleasant and potentially even dangerous side effects in some users. It’s ability to increase heart rate and blood pressure can be harmful to some people, including even healthy individuals. This is especially true if the stimulant is combined with caffeine. For this reason, if you should decide to take Nupehdrine, it is wise to avoid taking supplements with caffeine or ingesting caffeinated foods and beverages.

As for Hoodia, the manufacturer claims that its product contains the most purest form of Hoodia – “Real Certified Hoodia”. Hoodia, as you may or may not know, is believed to aid in appetite suppression and has reportedly been used for this purpose by bushmen in South Africa for centuries. That said, the scientific reality is that no form of hoodia – pure or not – has ever been found to be an effective appetite reducer.

Finally, caralluma fimbriata may help to aid Hoodia with appetite suppression by sending a signal to the brain that supposedly makes you feel full. Again, the evidence of its efficacy in this regard is lacking.

The bottom line is that there is zero proof that Nuphedrine is, in fact, an effective aid for weight loss. That being said, if your intention is to use it as part of your weight management program, be sure to use the product as directed (either based on the package or your doctor’s advice), including using it in conjunction with regular exercise and a healthy diet.

Individuals who are pregnant, nursing, planning on becoming pregnant or those currently taking medications or who have a known medical condition should first speak with their healthcare provider prior to taking this product.

At the time that this review was created, a single box of Nphedrine could be purchased from the official website for $89.99.

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